Chromium(VI) salts are possible contaminants of the chromium(III) pigments used as colorants in eyeshadow preparations. The\r\nuse of products containing these contaminants poses acute risks for sensitization and contact allergies. Chromium(VI) compounds\r\nare also classified as carcinogenic to humans (IARC group 1). An analytical method to analyse trace levels of chromium(VI) in\r\neyeshadow was developed in this study. The method is based on an extraction of the chromium(VI) from the sample using a\r\nmaximum extraction with alkali and additionally with synthetic lachrymal fluid to simulate physiological conditions. Following\r\nderivatization with 1,5-diphenylcarbazide, the extracted chromium(VI) is then quantified by spectrophotometry (540nm).\r\nValidation tests indicated a method standard deviation (inter- and intraday) of 8.7% and a linear range up to 25 mg/kg. The\r\naverage recovery was 107.9%, and the detection limit was 2.7 mg/kg. The applicability of the procedure was confirmed by the\r\nanalysis of pigments and authentic eyeshadow matrices.
Loading....